Diphtheria (Corynebacterium diphtheriae)

Corynebacteria are Gram-positive, aerobic, nonmotile, rod-shaped bacteria related to the Actinomycetes. They do not form spores or branch as do the actinomycetes, ostensibly they ware the distinction of forming irregular shaped, club-shaped or V-shaped arrangements in chemical formula growth. They endure snapping movements just after cell division which brings them into characteristic arrangements resembling Chinese letters. The genus Corynebacteria consists of a respective(a) group of bacteria including animal and coif pathogens, as well as saprophytes. Some corynebacteria are wear out of the normal flora of world, finding a suitable inlet in virtually every anatomical site. The best know and most widely canvas species is Corynebacterium diphtheriae, the causal broker of the infirmity diphtheria. History and Background No bacterial disease of humans has been as success plenteousy studied as diphtheria. The etiology, mode of transmission, unhealthful mechanism and molecular terra firma of exotoxin structure, function, and action have been clearly established. Consequently, passing effective methods of treatment and prevention of diphtheria have been developed. The study of Corynebacterium diphtheriae traces well-nigh the development of medical microbiology, immunology and molecular biology. Many contributions to these fields, as well as to our understanding of host-bacterial interactions, have been made studying diphtheria and the diphtheria toxin. Hippocrates provided the rootage clinical description of diphtheria in the 4th century B.C.

in that respect are also refere nces to the disease in ancient Syria and Egy! pt. In the 17th century, murderous pandemics of diphtheria swept Europe; in Spain El garatillo (the strangler), in Italy and Sicily, the gullet disease. In the 18th century, the disease reached the American colonies and reached epidemic proportions in 1735. Often, whole families died of the disease in a a couple of(prenominal) weeks. The bacterium that caused diphtheria was first described by Klebs in 1883, and was civil by Loeffler in 1884, who applied Kochs postulates and properly identified Corynebacterium... If you require to get a full essay, order it on our website: OrderCustomPaper.com

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